Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease

Fu Xianzhao; Huang Guang Ming; Qiu Hai Xian; Li Chunyan; Huang Wenhua; Cao Qiuxia; Lu Mian

doi:doi:10.11648/j.sjph.20200806.12

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Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease

Fu Xianzhao, Huang Guang Ming, Qiu Hai Xian, Li Chunyan, Huang Wenhua, Cao Qiuxia, Lu Mian

Published in Science Journal of Public Health (Volume 8, Issue 6)

Received: 19 September 2020 Published: 4 November 2020

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Abstract

Objective: To investigate the immune regulation of "nourishing Yin and Qi, activating blood circulation and detoxifying" in elderly diabetic patients complicated with acute coronary syndrome (ACS), and analyze its possible mechanisms. Methods: 69 diabetic patients aged 50-75 years and complicated with ACS, from March 2019 to February 2020 in the Department of Cardiology and Traditional Chinese medicine (TCM) in the Affiliated Hospital of Youjiang Medical University for Nationalities were randomly divided into control group (34 cases) and treatment group (35 cases). The control group was given western medicine standardized treatment, while the treatment group were treated with HJJR on the basis of routine Western medical treatment, and the therapeutic course for al1 were 2 months. Before and after treating, in the two groups, the levels of pro-inflammatory factors [C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor - α (TNF - α) and anti-inflammatory factors [IL-10, adiponectin (ADPN)] were detected. The clinical symptoms of chest tightness, chest pain, attacking frequency and duration, palpitation, shortness of breath, fatigue and the total scores of syndromes in the two groups were detected. At the same time, electrocardiogram (ECG) changes and adverse reactions were observed. Results: Compared with before treatment, after treating, the levels of pro-inflammatory factors CRP, IL-8, TNF - α in the two groups were evidently decreased, while the anti-inflammatory factors IL-10 and ADPN were obviously increased, but the changes in the treatment group were more significant (all P<0.05); the scores of frequency chest tightness and chest pain in both groups were decreased, while the duration of chest tightness and chest pain, fatigue and total score of TCM syndromes in the treatment group were significantly lower than those in the control group (all P<0.05); the number of ST down segment, T-wave flattening, T-wave inversion in ECG were significantly lower than before treatment, with more obviously increased in the treatment group, but no statistically significant. No other adverse reactions were found in the two groups during the medication. Conclusion: HJJR can significantly reduce the levels of CRP, IL-8, TNF - α, and increase the levels of IL-10 and ADPN in the serum of diabetic elderly patients complicated with ACS, suggesting that the effect of “nourishing yin and Qi, activating blood circulation and detoxifying” can regulate the balance mechanism of pro-inflammatory and anti-inflammatory factors, and bring into the protective effect on elderly diabetic patients with ACS.

Published in	Science Journal of Public Health (Volume 8, Issue 6)
DOI	10.11648/j.sjph.20200806.12
Page(s)	161-167
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Pro-inflammatory Cytokines, Anti-inflammatory Cytokines, Elderly Diabetes, Acute Coronary Syndrome, Huoxue Jiedu Jiangtang Recipe

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APA Style

Fu Xianzhao, Huang Guang Ming, Qiu Hai Xian, Li Chunyan, Huang Wenhua, et al. (2020). Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease. Science Journal of Public Health, 8(6), 161-167. https://doi.org/10.11648/j.sjph.20200806.12

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ACS Style

Fu Xianzhao; Huang Guang Ming; Qiu Hai Xian; Li Chunyan; Huang Wenhua, et al. Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease. Sci. J. Public Health 2020, 8(6), 161-167. doi: 10.11648/j.sjph.20200806.12

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AMA Style

Fu Xianzhao, Huang Guang Ming, Qiu Hai Xian, Li Chunyan, Huang Wenhua, et al. Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease. Sci J Public Health. 2020;8(6):161-167. doi: 10.11648/j.sjph.20200806.12

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@article{10.11648/j.sjph.20200806.12,
  author = {Fu Xianzhao and Huang Guang Ming and Qiu Hai Xian and Li Chunyan and Huang Wenhua and Cao Qiuxia and Lu Mian},
  title = {Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease},
  journal = {Science Journal of Public Health},
  volume = {8},
  number = {6},
  pages = {161-167},
  doi = {10.11648/j.sjph.20200806.12},
  url = {https://doi.org/10.11648/j.sjph.20200806.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20200806.12},
  abstract = {Objective: To investigate the immune regulation of "nourishing Yin and Qi, activating blood circulation and detoxifying" in elderly diabetic patients complicated with acute coronary syndrome (ACS), and analyze its possible mechanisms. Methods: 69 diabetic patients aged 50-75 years and complicated with ACS, from March 2019 to February 2020 in the Department of Cardiology and Traditional Chinese medicine (TCM) in the Affiliated Hospital of Youjiang Medical University for Nationalities were randomly divided into control group (34 cases) and treatment group (35 cases). The control group was given western medicine standardized treatment, while the treatment group were treated with HJJR on the basis of routine Western medical treatment, and the therapeutic course for al1 were 2 months. Before and after treating, in the two groups, the levels of pro-inflammatory factors [C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor - α (TNF - α) and anti-inflammatory factors [IL-10, adiponectin (ADPN)] were detected. The clinical symptoms of chest tightness, chest pain, attacking frequency and duration, palpitation, shortness of breath, fatigue and the total scores of syndromes in the two groups were detected. At the same time, electrocardiogram (ECG) changes and adverse reactions were observed. Results: Compared with before treatment, after treating, the levels of pro-inflammatory factors CRP, IL-8, TNF - α in the two groups were evidently decreased, while the anti-inflammatory factors IL-10 and ADPN were obviously increased, but the changes in the treatment group were more significant (all PConclusion: HJJR can significantly reduce the levels of CRP, IL-8, TNF - α, and increase the levels of IL-10 and ADPN in the serum of diabetic elderly patients complicated with ACS, suggesting that the effect of “nourishing yin and Qi, activating blood circulation and detoxifying” can regulate the balance mechanism of pro-inflammatory and anti-inflammatory factors, and bring into the protective effect on elderly diabetic patients with ACS.},
 year = {2020}
}

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TY  - JOUR
T1  - Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease
AU  - Fu Xianzhao
AU  - Huang Guang Ming
AU  - Qiu Hai Xian
AU  - Li Chunyan
AU  - Huang Wenhua
AU  - Cao Qiuxia
AU  - Lu Mian
Y1  - 2020/11/04
PY  - 2020
N1  - https://doi.org/10.11648/j.sjph.20200806.12
DO  - 10.11648/j.sjph.20200806.12
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 161
EP  - 167
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20200806.12
AB  - Objective: To investigate the immune regulation of "nourishing Yin and Qi, activating blood circulation and detoxifying" in elderly diabetic patients complicated with acute coronary syndrome (ACS), and analyze its possible mechanisms. Methods: 69 diabetic patients aged 50-75 years and complicated with ACS, from March 2019 to February 2020 in the Department of Cardiology and Traditional Chinese medicine (TCM) in the Affiliated Hospital of Youjiang Medical University for Nationalities were randomly divided into control group (34 cases) and treatment group (35 cases). The control group was given western medicine standardized treatment, while the treatment group were treated with HJJR on the basis of routine Western medical treatment, and the therapeutic course for al1 were 2 months. Before and after treating, in the two groups, the levels of pro-inflammatory factors [C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor - α (TNF - α) and anti-inflammatory factors [IL-10, adiponectin (ADPN)] were detected. The clinical symptoms of chest tightness, chest pain, attacking frequency and duration, palpitation, shortness of breath, fatigue and the total scores of syndromes in the two groups were detected. At the same time, electrocardiogram (ECG) changes and adverse reactions were observed. Results: Compared with before treatment, after treating, the levels of pro-inflammatory factors CRP, IL-8, TNF - α in the two groups were evidently decreased, while the anti-inflammatory factors IL-10 and ADPN were obviously increased, but the changes in the treatment group were more significant (all PConclusion: HJJR can significantly reduce the levels of CRP, IL-8, TNF - α, and increase the levels of IL-10 and ADPN in the serum of diabetic elderly patients complicated with ACS, suggesting that the effect of “nourishing yin and Qi, activating blood circulation and detoxifying” can regulate the balance mechanism of pro-inflammatory and anti-inflammatory factors, and bring into the protective effect on elderly diabetic patients with ACS.
VL  - 8
IS  - 6
ER  -

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Author Information

Fu Xianzhao

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Huang Guang Ming

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Qiu Hai Xian

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Li Chunyan

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Huang Wenhua

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Cao Qiuxia

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Lu Mian

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China

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APA Style

Fu Xianzhao, Huang Guang Ming, Qiu Hai Xian, Li Chunyan, Huang Wenhua, et al. (2020). Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease. Science Journal of Public Health, 8(6), 161-167. https://doi.org/10.11648/j.sjph.20200806.12

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ACS Style

Fu Xianzhao; Huang Guang Ming; Qiu Hai Xian; Li Chunyan; Huang Wenhua, et al. Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease. Sci. J. Public Health 2020, 8(6), 161-167. doi: 10.11648/j.sjph.20200806.12

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AMA Style

Fu Xianzhao, Huang Guang Ming, Qiu Hai Xian, Li Chunyan, Huang Wenhua, et al. Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease. Sci J Public Health. 2020;8(6):161-167. doi: 10.11648/j.sjph.20200806.12

Copy | Download

@article{10.11648/j.sjph.20200806.12,
  author = {Fu Xianzhao and Huang Guang Ming and Qiu Hai Xian and Li Chunyan and Huang Wenhua and Cao Qiuxia and Lu Mian},
  title = {Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease},
  journal = {Science Journal of Public Health},
  volume = {8},
  number = {6},
  pages = {161-167},
  doi = {10.11648/j.sjph.20200806.12},
  url = {https://doi.org/10.11648/j.sjph.20200806.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20200806.12},
  abstract = {Objective: To investigate the immune regulation of "nourishing Yin and Qi, activating blood circulation and detoxifying" in elderly diabetic patients complicated with acute coronary syndrome (ACS), and analyze its possible mechanisms. Methods: 69 diabetic patients aged 50-75 years and complicated with ACS, from March 2019 to February 2020 in the Department of Cardiology and Traditional Chinese medicine (TCM) in the Affiliated Hospital of Youjiang Medical University for Nationalities were randomly divided into control group (34 cases) and treatment group (35 cases). The control group was given western medicine standardized treatment, while the treatment group were treated with HJJR on the basis of routine Western medical treatment, and the therapeutic course for al1 were 2 months. Before and after treating, in the two groups, the levels of pro-inflammatory factors [C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor - α (TNF - α) and anti-inflammatory factors [IL-10, adiponectin (ADPN)] were detected. The clinical symptoms of chest tightness, chest pain, attacking frequency and duration, palpitation, shortness of breath, fatigue and the total scores of syndromes in the two groups were detected. At the same time, electrocardiogram (ECG) changes and adverse reactions were observed. Results: Compared with before treatment, after treating, the levels of pro-inflammatory factors CRP, IL-8, TNF - α in the two groups were evidently decreased, while the anti-inflammatory factors IL-10 and ADPN were obviously increased, but the changes in the treatment group were more significant (all PConclusion: HJJR can significantly reduce the levels of CRP, IL-8, TNF - α, and increase the levels of IL-10 and ADPN in the serum of diabetic elderly patients complicated with ACS, suggesting that the effect of “nourishing yin and Qi, activating blood circulation and detoxifying” can regulate the balance mechanism of pro-inflammatory and anti-inflammatory factors, and bring into the protective effect on elderly diabetic patients with ACS.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Immune Regulation of "Nourishing Yin and Qi, Activating Blood Circulation and Detoxifying" in Elderly Diabetic Patients Complicated with Coronary Heart Disease
AU  - Fu Xianzhao
AU  - Huang Guang Ming
AU  - Qiu Hai Xian
AU  - Li Chunyan
AU  - Huang Wenhua
AU  - Cao Qiuxia
AU  - Lu Mian
Y1  - 2020/11/04
PY  - 2020
N1  - https://doi.org/10.11648/j.sjph.20200806.12
DO  - 10.11648/j.sjph.20200806.12
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 161
EP  - 167
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20200806.12
AB  - Objective: To investigate the immune regulation of "nourishing Yin and Qi, activating blood circulation and detoxifying" in elderly diabetic patients complicated with acute coronary syndrome (ACS), and analyze its possible mechanisms. Methods: 69 diabetic patients aged 50-75 years and complicated with ACS, from March 2019 to February 2020 in the Department of Cardiology and Traditional Chinese medicine (TCM) in the Affiliated Hospital of Youjiang Medical University for Nationalities were randomly divided into control group (34 cases) and treatment group (35 cases). The control group was given western medicine standardized treatment, while the treatment group were treated with HJJR on the basis of routine Western medical treatment, and the therapeutic course for al1 were 2 months. Before and after treating, in the two groups, the levels of pro-inflammatory factors [C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor - α (TNF - α) and anti-inflammatory factors [IL-10, adiponectin (ADPN)] were detected. The clinical symptoms of chest tightness, chest pain, attacking frequency and duration, palpitation, shortness of breath, fatigue and the total scores of syndromes in the two groups were detected. At the same time, electrocardiogram (ECG) changes and adverse reactions were observed. Results: Compared with before treatment, after treating, the levels of pro-inflammatory factors CRP, IL-8, TNF - α in the two groups were evidently decreased, while the anti-inflammatory factors IL-10 and ADPN were obviously increased, but the changes in the treatment group were more significant (all PConclusion: HJJR can significantly reduce the levels of CRP, IL-8, TNF - α, and increase the levels of IL-10 and ADPN in the serum of diabetic elderly patients complicated with ACS, suggesting that the effect of “nourishing yin and Qi, activating blood circulation and detoxifying” can regulate the balance mechanism of pro-inflammatory and anti-inflammatory factors, and bring into the protective effect on elderly diabetic patients with ACS.
VL  - 8
IS  - 6
ER  -

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